Delft University of Technology Applied Sciences
Delft, (Zuid-Holland), 38 hours per week
Job description
This project aims at understanding how evolutionary adaptation to temperature cycles has contributed to shaping the regulation and kinetic properties of the metabolic network of yeast. Adaptation to temperature will be addressed at multiple levels, both at a genome-wide scale and, with a greater level of detail, by focusing on a specific pathway, namely glycolysis. This central pathway for sugar metabolism will be investigated by a multi-level ‘systems’ approach. This will involve incorporation of temperature in kinetic models of this key metabolic pathway. In addition to providing an understanding of core regulatory principles in industrial microorganisms, the research will contribute to improvements for specific industrial applications of yeast that involve dynamic temperature profiles. The project will be carried out within the Kluyver Centre for Genomics of Industrial Fermentation.
Requirements
Required education/skills:University Graduate
Applicants should have a strong background in both chemical/biochemical engineering and microbial physiology and should have an MSc degree, preferably in industrial or metabolic biotechnology. Related engineering or life science-oriented disciplines could be considered as well. In addition, the candidate should have a keen interest in experimental research in the field of industrial fermentation as related to theoretical developments, e.g. mathematical modelling. Candidates are expected to have good communication skills and team spirit. Fluency in English, both written and spoken, is a requirement for this position.
Job type: Research / Advising
Workfield(s):
- Research trainees, non-tenured lecturers, researchers
Organization
Delft University of Technology
Applied Sciences
Delft University of Technology (TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognized level. Education, research and design are strongly oriented towards applicability. TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At TU Delft you will work in an environment where technical sciences and society converge. TU Delft comprises eight faculties, unique laboratories, research institutes and schools.
The Department of Biotechnology is a world leader in the field of Industrial and Environmental Biotechnology. The department’s Bioprocess Technology section has broad experience in modelling bioreactor systems as well as microbial metabolism. More recently, the research interest has shifted towards developing new experimental hardware, analytical protocols and theoretical tools that allow the in-vivo analysis of the responses of microbial cells to environmental and genetic disturbances. The research focuses on primary carbon metabolism and its regulation.
Date of entry: 30/05/2008
Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000
Maximum salary amount in Euro's a month 2558
Employment basis: Temporary for specified period
Duration of the contract: Four years
Maximum hours per week: 38
Additional conditions of employment:
The successful candidate will be employed full-time by TU Delft for a fixed period of 4 years within which he or she is expected to write a dissertation leading to a doctoral degree (PhD thesis). The monthly salary for a PhD will be to a maximum of € 2558 gross in the fourth year.TU Delft offers an attractive benefits package, including a flexible work week, free high-speed Internet access from home, and the option of assembling a customized compensation and benefits package (the 'IKA'). Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. Delft University of Technology strives to increase the number of women in higher academic positions; women are therefore especially encouraged to apply.
Additional Information
Additional information about the vacancy can be obtained from:
Dr. W.M. van Gulik
Telephone number: 31(0)15-2784629
E-mail address: secr-bpt-tnw@tudelft.nl
Or additional information can be obtained through one of the following links:Application
You can apply for this job before 01-08-2008 (dd-mm-yyyy) by sending your application to:
Dr. W.M. van Gulik/Biotechnology
E-mail: secr-bpt-tnw@tudelft.nl
When applying for this job always mention the vacancynumber TNWBT08-045.
Job description
This project aims at understanding how evolutionary adaptation to temperature cycles has contributed to shaping the regulation and kinetic properties of the metabolic network of yeast. Adaptation to temperature will be addressed at multiple levels, both at a genome-wide scale and, with a greater level of detail, by focusing on a specific pathway, namely glycolysis. This central pathway for sugar metabolism will be investigated by a multi-level ‘systems’ approach. This will involve incorporation of temperature in kinetic models of this key metabolic pathway. In addition to providing an understanding of core regulatory principles in industrial microorganisms, the research will contribute to improvements for specific industrial applications of yeast that involve dynamic temperature profiles. The project will be carried out within the Kluyver Centre for Genomics of Industrial Fermentation.
Requirements
Required education/skills:University Graduate
Applicants should have a strong background in both chemical/biochemical engineering and microbial physiology and should have an MSc degree, preferably in industrial or metabolic biotechnology. Related engineering or life science-oriented disciplines could be considered as well. In addition, the candidate should have a keen interest in experimental research in the field of industrial fermentation as related to theoretical developments, e.g. mathematical modelling. Candidates are expected to have good communication skills and team spirit. Fluency in English, both written and spoken, is a requirement for this position.
Job type: Research / Advising
Workfield(s):
- Research trainees, non-tenured lecturers, researchers
Organization
Delft University of Technology
Applied Sciences
Delft University of Technology (TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognized level. Education, research and design are strongly oriented towards applicability. TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At TU Delft you will work in an environment where technical sciences and society converge. TU Delft comprises eight faculties, unique laboratories, research institutes and schools.
The Department of Biotechnology is a world leader in the field of Industrial and Environmental Biotechnology. The department’s Bioprocess Technology section has broad experience in modelling bioreactor systems as well as microbial metabolism. More recently, the research interest has shifted towards developing new experimental hardware, analytical protocols and theoretical tools that allow the in-vivo analysis of the responses of microbial cells to environmental and genetic disturbances. The research focuses on primary carbon metabolism and its regulation.
Date of entry: 30/05/2008
Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000
Maximum salary amount in Euro's a month 2558
Employment basis: Temporary for specified period
Duration of the contract: Four years
Maximum hours per week: 38
Additional conditions of employment:
The successful candidate will be employed full-time by TU Delft for a fixed period of 4 years within which he or she is expected to write a dissertation leading to a doctoral degree (PhD thesis). The monthly salary for a PhD will be to a maximum of € 2558 gross in the fourth year.TU Delft offers an attractive benefits package, including a flexible work week, free high-speed Internet access from home, and the option of assembling a customized compensation and benefits package (the 'IKA'). Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. Delft University of Technology strives to increase the number of women in higher academic positions; women are therefore especially encouraged to apply.
Additional Information
Additional information about the vacancy can be obtained from:
Dr. W.M. van Gulik
Telephone number: 31(0)15-2784629
E-mail address: secr-bpt-tnw@tudelft.nl
Or additional information can be obtained through one of the following links:Application
You can apply for this job before 01-08-2008 (dd-mm-yyyy) by sending your application to:
Dr. W.M. van Gulik/Biotechnology
E-mail: secr-bpt-tnw@tudelft.nl
When applying for this job always mention the vacancynumber TNWBT08-045.
