Utrecht University
(Utrecht), 38 hours per week
Job description
Function title: PhD-researcher on a project entitled “Molecular dissection of a lipid pump involved in membrane vesiculation”
A central dogma in cell biology is that membrane vesicle formation is driven by the assembly of cytosolic coat proteins. Yet recent work shows that a group of putative lipid transporters also plays a critical role in this process. These so-called P4 ATPases are essential for creating membrane lipid asymmetry and form heteromeric complexes with members of the Cdc50 protein family.
The group of Joost Holthuis offers a PhD student position to dissect the working mechanism of the P4 ATPase/CDC50 class of lipid pumps and to investigate how these activities contribute to membrane vesiculation. The experimental approach will encompass a powerful combination of biochemical, biophysical and genetic methods. The successful applicant will join a young, highly motivated and international team of researchers with expertise in membrane protein chemistry, lipid enzymology, yeast genetics and molecular cell biology. The project is part of an interdisciplinary collaboration with the group of Dr Leo Klomp at the Utrecht Medical Center, who pioneers diseases that are due to defective P4 ATPases. The project is funded generously by the High Potential Program of Utrecht University and the Netherlands Organisation for Scientific Research NWO.
Requirements
Required education/skills:University Graduate
We are looking for an ambitious and interactive individual with a Master degree in (bio)chemistry, biology or (bio)physics. Skills in protein and/or lipid chemistry would be advantageous, but are not obligatory; perseverance and the aspiration to work in a stimulating environment are more important.
Job type: Research / Advising
Workfield(s):
- Research trainees, non-tenured lecturers, researchers(Scientific discipline: Natural Sciences)
Organization
Utrecht University
Faculty of Science
The Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty's academic programmes reflect developments in today's society.
Institute of Biomembranes
The Institute of Biomembranes www.biomembranes.nl is an interdisciplinary research institute and graduate school at Utrecht University, accommodating 18 research groups from the faculties of Science (Biology and Chemistry), Medicine, and Veterinary Medicine. Its scientific mission focuses on the following three themes:
(1) structure, function and organization of lipids and proteins in biological membranes;
(2) biogenesis of membranes and the transport and sorting of lipids and proteins;
(3) the role of biomembranes in signal transduction via membrane receptors, cell-cell-, and cell-matrix interactions.
In the group of Dr Joost Holthuis, Department of Chemistry, a position is available for a PhD-researcher on a project entitled “Molecular dissection of a lipid pump involved in membrane vesiculation”
Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000
Salary: scale 10.
Maximum salary amount in Euro's a month 2558
Employment basis: Temporary for specified period
Duration of the contract: Minimum 1 year and maximum 4 years
Maximum hours per week: 38
Additional conditions of employment:
We offer a full-time position for minimum 1 year and maximum 4 years. Your gross salary starts with € 2,000.- per month in the first year and amount to € 2,558.- in the fourth year of employment.
The salary is supplemented with a holiday bonus of 8% and an end-of-year bonus of 6,4% per year. In addition we offer: a pension scheme, a partially paid parental leave, flexible employment conditions in which you may trade salary for vacation days or vice versa. Conditions are based on the Collective Employment Agreement of the Dutch Universities. The research group will provide the candidate with necessary support on all aspects of the project.
Additional Information
Additional information about the vacancy can be obtained from:
Dr Joost Holthuis
Telephone number: 31 (0)30 253 6630
E-mail address: j.c.holthuis@uu.nl
Or additional information can be obtained through one of the following links:
You can apply for this job before 15-07-2008 (dd-mm-yyyy) by sending your application to:
Faculty of Science
P&O
Please send by email
E-mail: Science.Peno@uu.nl
When applying for this job always mention the vacancynumber 65813.
Job description
Function title: PhD-researcher on a project entitled “Molecular dissection of a lipid pump involved in membrane vesiculation”
A central dogma in cell biology is that membrane vesicle formation is driven by the assembly of cytosolic coat proteins. Yet recent work shows that a group of putative lipid transporters also plays a critical role in this process. These so-called P4 ATPases are essential for creating membrane lipid asymmetry and form heteromeric complexes with members of the Cdc50 protein family.
The group of Joost Holthuis offers a PhD student position to dissect the working mechanism of the P4 ATPase/CDC50 class of lipid pumps and to investigate how these activities contribute to membrane vesiculation. The experimental approach will encompass a powerful combination of biochemical, biophysical and genetic methods. The successful applicant will join a young, highly motivated and international team of researchers with expertise in membrane protein chemistry, lipid enzymology, yeast genetics and molecular cell biology. The project is part of an interdisciplinary collaboration with the group of Dr Leo Klomp at the Utrecht Medical Center, who pioneers diseases that are due to defective P4 ATPases. The project is funded generously by the High Potential Program of Utrecht University and the Netherlands Organisation for Scientific Research NWO.
Requirements
Required education/skills:University Graduate
We are looking for an ambitious and interactive individual with a Master degree in (bio)chemistry, biology or (bio)physics. Skills in protein and/or lipid chemistry would be advantageous, but are not obligatory; perseverance and the aspiration to work in a stimulating environment are more important.
Job type: Research / Advising
Workfield(s):
- Research trainees, non-tenured lecturers, researchers(Scientific discipline: Natural Sciences)
Organization
Utrecht University
Faculty of Science
The Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty's academic programmes reflect developments in today's society.
Institute of Biomembranes
The Institute of Biomembranes www.biomembranes.nl is an interdisciplinary research institute and graduate school at Utrecht University, accommodating 18 research groups from the faculties of Science (Biology and Chemistry), Medicine, and Veterinary Medicine. Its scientific mission focuses on the following three themes:
(1) structure, function and organization of lipids and proteins in biological membranes;
(2) biogenesis of membranes and the transport and sorting of lipids and proteins;
(3) the role of biomembranes in signal transduction via membrane receptors, cell-cell-, and cell-matrix interactions.
In the group of Dr Joost Holthuis, Department of Chemistry, a position is available for a PhD-researcher on a project entitled “Molecular dissection of a lipid pump involved in membrane vesiculation”
Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000
Salary: scale 10.
Maximum salary amount in Euro's a month 2558
Employment basis: Temporary for specified period
Duration of the contract: Minimum 1 year and maximum 4 years
Maximum hours per week: 38
Additional conditions of employment:
We offer a full-time position for minimum 1 year and maximum 4 years. Your gross salary starts with € 2,000.- per month in the first year and amount to € 2,558.- in the fourth year of employment.
The salary is supplemented with a holiday bonus of 8% and an end-of-year bonus of 6,4% per year. In addition we offer: a pension scheme, a partially paid parental leave, flexible employment conditions in which you may trade salary for vacation days or vice versa. Conditions are based on the Collective Employment Agreement of the Dutch Universities. The research group will provide the candidate with necessary support on all aspects of the project.
Additional Information
Additional information about the vacancy can be obtained from:
Dr Joost Holthuis
Telephone number: 31 (0)30 253 6630
E-mail address: j.c.holthuis@uu.nl
Or additional information can be obtained through one of the following links:
- About the organization (http://www.biomembranes.nl/)
- Further information on our research and research environment (http://www.me.chem.uu.nl/groupmembers/joost/holthuis.html)
You can apply for this job before 15-07-2008 (dd-mm-yyyy) by sending your application to:
Faculty of Science
P&O
Please send by email
E-mail: Science.Peno@uu.nl
When applying for this job always mention the vacancynumber 65813.
