Project:
“Characterisation and functional analysis of Fusarium oxysporum effectors”.
Fusarium oxysporum f.sp. lycopersici (Fol) is the causal agent of tomato wilt disease. This project aims at the functional characterization of proteins secreted by Fol upon invasion of the xylem vessels of tomato. Some of these proteins may trigger induction of basal defences, whereas others (called effectors) may suppress these responses allowing the pathogen to cause disease. Analysis of the xylem sap proteome of Fol-infected tomato plants resulted in identification of a large set of Fol secreted proteins. Here, we want to identify the function of these secreted proteins in disease, and identify their molecular targets in the plant. For this research a variety of techniques will be used including (transient)transgenesis, epitope-tagging, proteomics, disease bioassays and confocal microscopy.
Requirements
The ideal candidate must hold a Master’s degree (or equivalent) in Molecular Biology, have good communication skills, be able to work in a team and be highly motivated to conduct fundamental scientific research.
Job application
Applications, quoting the vacancy number and marked “strictly confidential” (in the upper left-hand corner of the envelope) should include a curriculum vitae and the names and addresses of three person from which information about the candidate can be obtained.
The application should be sent to the Personnel Department, Universiteit van Amsterdam, Faculty of Science, Kruislaan 404, 1098 SM Amsterdam, the Netherlands. Applications can also be e-mailed to application@science.uva.nl, also bearing the vacancy number and the other documents as attachments.
The closing date for application is June 2nd 2008.
Further information
For more information, contact Dr. F.L.W. Takken, phone + 31 20-525 7795, e-mail: takken@science.uva.nl or Prof. B.J.C. Cornelissen, phone + 31 20-525 7707, e-mail: cornelissen@science.uva.nl. For links to more information about the UvA or SILS see: http://home.medewerker.uva.nl/f.l.w.takken/
Information on the CBSG can be found at: http://www.cbsg.nl/
