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Tuesday, April 15, 2008

UK: Newcastle University Mechanisms Regulating Nuclear Hormone Receptor Expression and Signalling in Human Breast Cancer & Myometrial Cell Lines

Institute of Cellular Medicine

Reference Code: SAR27

Closing Date: 24th June 2008

Details:
Supervisors: Dr Alison Tyson-Capper, Dr David Elliott
Institute: Institute of Cellular Medicine
Sponsor: Dr William Harker Foundation
Duration: 4 years

Alternative pre-mRNA splicing plays an important role in reproductive biology and development. Alternative splicing events also have the potential to both cause and effect tumour progression. This studentship offers an excellent research training opportunity to work in an environment focusing on one of the most exciting areas of RNA biology. The proposed project will investigate the factors and mechanisms that effect co-transcriptional and splicing decisions of nuclear hormone receptors in different cell types. The student will explore the role of specfic DNA- and RNA- binding proteins by combining techniques including Ch-IP (Chromatin Immuno-Precipitations) and CLIP (Cross Linking Immuno- Precipitation), respectively.

As part of the research training for this project, you will undertake the MRes in Medical and Molecular Biosciences.

Person specification
Applicants should hold, or expect to obtain, a first-class or upper-second-class Honours degree in any area of biological science.

Value of the award and eligibility
Due to funding criteria, this award is available to UK and other EU nationals only. The award covers fees and a stipend starting at £12,940 per annum.

How to apply
You must complete the University's postgraduate application form, quoting the reference number SAR27, and attaching a copy of your CV and covering letter. Select "MRes/PhD in Medical Sciences" as the programme of study.

Closing date: 24 June 2008

Further information
The project will start in September 2008. For further information regarding this studentship please contact Dr Alison Tyson-Capper, a.j.tyson-capper@ncl.ac.uk or Dr David Elliott, david.elliott@ncl.ac.uk