Title: Disturbance of thiamine (vitamin B1) metabolism in diabetes and vascular complications
Clinical Sciences Research Institute, Warwick Medical School
Applications are invited for a 3-year PhD studentship funded by Diabetes UK in Warwick Medical School, University of Warwick, Coventry, U.K. The title of the project is "Mechanism of increased renal clearance of thiamine in hyperglycaemia associated with diabetes" supervised by Professor Paul J Thornalley and Dr Naila Rabbani. The project builds on the recent finding by this team of a profound increase in renal clearance of thiamine (vitamin B1) in clinical type 1 and type 2 diabetes leading to low thiamine concentration in plasma and tissues where complications of diabetes arise (Diabetologia 50, 2164 - 2170, 2007). High dose thiamine supplements hold promise of therapy for prevention of vascular complications in diabetes. The host team of this project are participating in on-going clinical trials. The aim of this investigation is to characterise the mechanism of increased renal clearance of thiamine in diabetes that causes plasma thiamine deficiency and increased risk of developing microvascular complications. The project outcome will likely support therapeutic decisions in diabetes and identify new strategies to maintain thiamine sufficiency in diabetes.
You should hold, or expect to receive, a first or upper second class honours degree or equivalent in biochemistry, cell biology, cellular and molecular biology, pharmacology, biomedical science, medical sciences or related subject. The successful candidate will enrol on a full-time programme of research studies leading to the award of the degree of Doctor of Philosophy. The studentship will comprise fees (at the Home and EU rate only) and an annual stipend of £13,000 pa, increasing to £14,000 pa over 3 years. The studentship will be awarded for a period of up to three years subject to satisfactory progress. The studentship is tenable in the Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, U.K.
Informal enquiries should be directed to Paul Thornalley (e-mail: P.J.Thornalley@warwick.ac.uk, tel +44 (0) 24 7696 8594) or Naila Rabbani (e-mail: N.Rabbani@warwick.ac.uk, tel +44 (0) 24 7696 8593).
To apply, please complete the online application form at http://www2.warwick.ac.uk/fac/med/study/researchdegrees/ Please put the name of the studentship and the post number on the application form. Please also send a current CV and covering letter to Professor Paul J Thornalley, Clinical Sciences Research Institute, Warwick Medical School, University Hospital, Coventry CV2 2DX, U.K. Two signed original academic references should also be sent to Samantha Plumb, Research Secretary, Warwick Medical School, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL UK Tel: +44 (0) 24 765 75208 Fax: 024 7652 8375 s.plumb@warwick.ac.uk
Interview date: Proposed May 2008
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Click here for an application form. Please clearly state in the Academic interests and purpose of study section the title of the PhD study you are applying for. To receive a hard copy application pack, please contact Human Resources, on +44(0)24 7657 5810 (24 hour answer phone), or by e-mail to WMSpersonnel@warwick.ac.uk.
An application form must be completed if you wish to be considered for this post. Please note that the hard copy application pack and the on-line application pack are the same.
Please quote job vacancy reference number WMS12-048.
The closing date/time for applications is midnight (British time) at the end of Friday 02 May 2008.
